Lord Dowding Fund for humane research

 

National Antivisection Society

The Lord Dowding Fund

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3. The Scientific Steering Committee’s five examples of diseases of concern

Please click for the SSC listed diseases of concern and ADI’s response: (a) AIDS (b) malaria (c) tuberculosis (d) hepatitis (e) immune-based diseases (arthritis, multiple sclerosis, type...

3. The Scientific Steering Committee’s five examples of diseases of concern

(a) AIDS SSC: “The etiologic agent HIV-1 is an example of a virus with a very complex interaction with the immune system and a very limited host range. It only readily infects humans and to a lesser...

3. The Scientific Steering Committee’s five examples of diseases of concern

(b) Malaria SSC: “The relationship between the parasite and the host is quite specific”. {h1ADI Response:{/h1 ADI agrees with the Scientific Steering Committee that the relationship between the...

3. The Scientific Steering Committee’s five examples of diseases of concern

(c) Tuberculosis SSC: “A careful analysis of two macaque models (rhesus and cynomologus) has shown the value of these two models and their similarity to the human situation”. “These models are being...

3. The Scientific Steering Committee’s five examples of diseases of concern

(d) Hepatitis SSC: “Hepatitis C cannot be cultured”. {h1ADI Response:{/h1 This is no longer correct. A recent paper reported partial progress, which has resulted in some techniques that can be...

3. The Scientific Steering Committee’s five examples of diseases of concern

(e) Immune-based diseases SSC: “Non-human primate models…are needed for the development and evaluation of new immunomodulatory/immunosuppressive therapies”. {h1ADI Response, Multiple Sclerosis:{/h1 The...

SSC: problems faced in developing vaccines or therapeutics

SSC: 1) Host-viral/parasite relationship: (a) For instance some agents such as HCV and malaria intra-hepatic stages cannot be cultured in vitro or, they are is so species specific that they only infect...

SSC: problems faced in developing vaccines or therapeutics

SSC: 2) Specificity of new generation drugs/biologicals. New generation therapeutics are often so specific that sometimes a change in a single amino acid can result in the difference between a beneficial...

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